PKM2 Antikörper (AA 36-40)

Produktnummer ABIN871666

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PKM2 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PKM2 Antikörper (AA 36-40) (ABIN871666)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PKM2 Antikörper

Bindungsspezifität: AA 36-40

Spezifität: The antibody detects endogenous levels of total PKM1/2 protein.

Aufreinigung: Affinity purified

Immunogen: Peptide sequence around AA 36-40 (D-S-P-P-I) derived from Human PKM1, 2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Anwendungsinformationen

Applikationshinweise: Western blotting: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung: PKM2

Hintergrund: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Molekulargewicht: 60 kDa

Gen-ID: 5315

NCBI Accession: NP_872270

UniProt: P14618

Pathways: Warburg Effekt