ATM Antikörper

Produktnummer ABIN865431

Der Maus Monoklonal anti-ATM Antikörper (Klon 5C5) (ABIN865431) detektiert spezifisch ATM in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ATM Antikörper (ABIN865431)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ATM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 5C5

Produktdetails anti-ATM Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human ATM expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100g/100l

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Andere Bezeichnung: ATM

Hintergrund: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes. Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM

Molekulargewicht: 351kDa

Gen-ID: 472

Pathways: p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus