PKM2 Antikörper (AA 399-403)

Produktnummer ABIN783340

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PKM2 in WB. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für PKM2 Antikörper (AA 399-403) (ABIN783340)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PKM2 Antikörper

Bindungsspezifität: AA 399-403

Sequenz: V-R-A-S-S

Spezifität: This antibody detects endogenous levels of total PKM1 protein.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse

Aufreinigung: Affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around aa. 399~403

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung: PKM2

Hintergrund: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.Synonyms: CTHBP, Cytosolic thyroid hormone-binding protein, M2-PK, OIP-3, OIP3, Opa-interacting protein 3, PK2, PK3, PKM, Pyruvate kinase 2/3, Pyruvate kinase M1/M2, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Pyruvate kinase muscle isozyme, THBP1

Molekulargewicht: 60 kDa

Gen-ID: 5315

NCBI Accession: NP_002645

UniProt: P14618

Pathways: Warburg Effekt