MECP2 Antikörper (AA 313-363)

Produktnummer ABIN8122899

Der Kaninchen Polyklonal anti-MECP2 Antikörper wird verwendet zum Nachweis von MECP2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für MECP2 Antikörper (AA 313-363) (ABIN8122899)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MECP2 Antikörper

Bindungsspezifität: AA 313-363

Verwendungszweck: MeCP2 Antibody

Spezifität: The antibody detects endogenous MeCP2 proteins.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic Peptide of MeCP2 AA range: 313-363

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, containing 0.5 % BSA, 0.02 % sodium azide as Preservative and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2

Hintergrund:

Synonyms: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor

Gene Name: MECP2

Protein Name: Methyl-CpG-binding protein 2

Gen-ID: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane