GLI1 Antikörper (AA 800-1057) (Fluoro647)

Produktnummer ABIN8055282

Der Kaninchen Polyklonal anti-GLI1 Antikörper wird verwendet zum Nachweis von GLI1 in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für GLI1 Antikörper (AA 800-1057) (Fluoro647) (ABIN8055282)

Target: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLI1 Antikörper ist konjugiert mit Fluoro647

Applikation: Flow Cytometry (FACS)

Produktdetails anti-GLI1 Antikörper (Fluoro647)

Bindungsspezifität: AA 800-1057

Verwendungszweck: Anti-GLI1 Antibody Fluoro647 Conjugated

Homologie: Human GLI1 shares 79.8% amino acid (aa) sequence identity with mouse GLI1.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human GLI1 recombinant protein (Position: Y800-Q1057). Human GLI1 shares 79.8% amino acid (aa) sequence identity with mouse GLI1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu GLI1

Target: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Andere Bezeichnung: GLI1

Hintergrund:

Background: GLI1, also known as GLI, is a protein originally isolated in human glioblastoma. The protein is encoded by GLI1 gene. It is mapped to 12q13.3. This gene is a member of a select group of cellular genes that are genetically altered in primary human tumors. GLI1 encodes a member of the GLI-Kruppel family of zinc finger proteins in the final steps of Hedgehog signaling in normal development and disease. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Beside, various upstream patterning signals may be integrated by the Gli proteins to a coherent programme of neurogenesis.

Gene Full Name: GLI family zinc finger 1

Gen-ID: 2735

UniProt: P08151

Pathways: Hedgehog Signalweg, Dopaminergic Neurogenesis