STIM1 Antikörper (AA 42-599) (Cy3)

Produktnummer ABIN8043106

Der Cy3-konjugierte Kaninchen Polyklonal anti-STIM1 Antikörper (ABIN8043106) detektiert spezifisch STIM1 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Maus.

Kurzübersicht für STIM1 Antikörper (AA 42-599) (Cy3) (ABIN8043106)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STIM1 Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS)

Produktdetails anti-STIM1 Antikörper (Cy3)

Bindungsspezifität: AA 42-599

Verwendungszweck: Anti-STIM1 Antibody Cy3 Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human STIM1 shares 98.2%,98% amino acid (aa) sequence identity with mouse,rat STIM1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human STIM1 recombinant protein (Position: E42-L599). Human STIM1 shares 98.2% and 98% amino acid (aa) sequence identity with mouse and rat STIM1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Andere Bezeichnung: STIM1

Hintergrund:

Background: Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene. STIM1 has a single transmembranedomain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane. This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: stromal interaction molecule 1

Gen-ID: 6786

UniProt: Q13586

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling