SMPD3 Antikörper (AA 184-553) (HRP)

Produktnummer ABIN8041680

Der Kaninchen Polyklonal anti-SMPD3 Antikörper wird verwendet zum Nachweis von SMPD3 in Proben von Human. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für SMPD3 Antikörper (AA 184-553) (HRP) (ABIN8041680)

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMPD3 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SMPD3 Antikörper (HRP)

Bindungsspezifität: AA 184-553

Verwendungszweck: Anti-SMPD3 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human SMPD3 shares 88.9% amino acid (aa) sequence identity with both mouse,rat SMPD3.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SMPD3 recombinant protein (Position: F184-D553). Human SMPD3 shares 88.9% amino acid (aa) sequence identity with both mouse and rat SMPD3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu SMPD3

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Andere Bezeichnung: SMPD3

Hintergrund:

Background: Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene. SMPD3 (Sphingomyelin phosphodiesterase 3, also Neutral sphingomyelinase 2/nSMase2) is a 69-74 kDa member of the neutral sphingomyelinase family of enzymes. It is a monomeric Golgi/plasma membrane enzyme that converts sphingomyelin (a plasma membrane lipid) into ceramide and phosphorylcholine. This generates second messenger components that participate in signal transduction. Human SMPD3 is a two transmembrane, 655 amino acids molecule. It contains an N-terminal luminal segment (aa 1-10), a cytoplasmic region (aa 32-64), and one catalytic domain (aa 340-646). Phosphorylation increases its MW to 78 kDa in SDS-PAGE. There is one potential isoform that possesses an Asn substitution for aa 569-587. Over aa 2-655, human SMPD3 shares 91 % aa sequence identity with mouse SMPD3.

Gene Full Name: sphingomyelin phosphodiesterase 3

Gen-ID: 55512

UniProt: Q9NY59

Pathways: Hormone Transport