SMPD3 Antikörper (AA 416-655)

Produktnummer ABIN6148146

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SMPD3 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SMPD3 Antikörper (AA 416-655) (ABIN6148146)

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMPD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SMPD3 Antikörper

Bindungsspezifität: AA 416-655

Sequenz: MDVAYHCYPN KCNDDALASK GALFLKVQVG STPQDQRIVG YIACTHLHAP QEDSAIRCGQ LDLLQDWLAD FRKSTSSSSA ANPEELVAFD VVCGDFNFDN CSSDDKLEQQ HSLFTHYRDP CRLGPGEEKP WAIGTLLDTN GLYDEDVCTP DNLQKVLESE EGRREYLAFP TSKSSGQKGR KELLKGNGRR IDYMLHAEEG LCPDWKAEVE EFSFITQLSG LTDHLPVAMR LMVSSGEEEA

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 416-655 of human SMPD3 (NP_061137.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:1000 - 1:3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SMPD3

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Andere Bezeichnung: SMPD3

Hintergrund: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Binds to anionic phospholipids (APLs such as phosphatidylserine (PS and phosphatidic acid (PA that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity.,SMPD3,NSMASE2,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,Cell Type Marker,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Oligodendrocyte marker,Neuron marker,SMPD3

Molekulargewicht: 70 kDa/71 kDa

Gen-ID: 55512

UniProt: Q9NY59

Pathways: Hormone Transport