SMPD3 Antikörper (Middle Region)

Produktnummer ABIN2783713

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-SMPD3 Antikörper wird verwendet zum Nachweis von SMPD3 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd und Kaninchen. Er wurde validiert für WB.

Kurzübersicht für SMPD3 Antikörper (Middle Region) (ABIN2783713)

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMPD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SMPD3 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: SMPD3 Antibody - middle region

Sequenz: RPPEADDPVP GGQARNGAGG GPRGQTPNHN QQDGDSGSLG SPSASRESLV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SMPD3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMPD3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49331-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SMPD3 Antikörper (ABIN2783713)

Tani, Hannun: "Analysis of membrane topology of neutral sphingomyelinase 2." in: FEBS letters, Vol. 581, Issue 7, pp. 1323-8, (2007) (PubMed).

Details zu SMPD3

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Andere Bezeichnung: SMPD3

Hintergrund:

Background Information: SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. SMPD3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.

Gene Name: Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)

Alternative Symbols: NSMASE2

Protein Name: Sphingomyelin phosphodiesterase 3

Molekulargewicht: 71kDa

Gen-ID: 55512

NCBI Accession: NP_061137

UniProt: Q9NY59

Pathways: Hormone Transport