Retinoblastoma Binding Protein 8 Antikörper (AA 307-702) (HRP)

Produktnummer ABIN8031825

Der Kaninchen Polyklonal anti-Retinoblastoma Binding Protein 8 Antikörper wird verwendet zum Nachweis von Retinoblastoma Binding Protein 8 in Proben von Human und Maus. Er wurde validiert für ELISA, WB und IHC.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (AA 307-702) (HRP) (ABIN8031825)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper (HRP)

Bindungsspezifität: AA 307-702

Verwendungszweck: Anti-RBBP8 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human RBBP8 shares 68.9%,66.7% amino acid (aa) sequence identity with mouse,rat RBBP8,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human RBBP8 recombinant protein (Position: R307-K702). Human RBBP8 shares 68.9% and 66.7% amino acid (aa) sequence identity with mouse and rat RBBP8, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: RBBP8

Hintergrund:

Background: Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene. The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind ly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Gene Full Name: RB binding protein 8, endonuclease

Gen-ID: 5932

UniProt: Q99708

Pathways: Zellzyklus, DNA Reparatur