Retinoblastoma Binding Protein 8 Antikörper (AA 307-702) (Fluoro488)

Produktnummer ABIN8031821

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Retinoblastoma Binding Protein 8 in FACS. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (AA 307-702) (Fluoro488) (ABIN8031821)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper (Fluoro488)

Bindungsspezifität: AA 307-702

Verwendungszweck: Anti-RBBP8 Antibody Fluoro488 Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human RBBP8 shares 68.9%,66.7% amino acid (aa) sequence identity with mouse,rat RBBP8,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human RBBP8 recombinant protein (Position: R307-K702). Human RBBP8 shares 68.9% and 66.7% amino acid (aa) sequence identity with mouse and rat RBBP8, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: RBBP8

Hintergrund:

Background: Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene. The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind ly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Gene Full Name: RB binding protein 8, endonuclease

Gen-ID: 5932

UniProt: Q99708

Pathways: Zellzyklus, DNA Reparatur