PIK3AP1 Antikörper (AA 78-583) (HRP)

Produktnummer ABIN8021852

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PIK3AP1 in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PIK3AP1 Antikörper (AA 78-583) (HRP) (ABIN8021852)

Target: PIK3AP1 (phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3AP1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-PIK3AP1 Antikörper (HRP)

Bindungsspezifität: AA 78-583

Verwendungszweck: Anti-PIK3AP1 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human PIK3AP1 shares 83.8% amino acid (aa) sequence identity with mouse PIK3AP1.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PIK3AP1 recombinant protein (Position: H78-R583). Human PIK3AP1 shares 83.8% amino acid (aa) sequence identity with mouse PIK3AP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu PIK3AP1

Target: PIK3AP1 (phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1))

Andere Bezeichnung: PIK3AP1

Hintergrund:

Background: Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene. BCAP (B cell adaptor for phosphoinositide 3-kinase (PI3K)), also known as PI3KAP1, participates in linking the B cell antigen receptor (BCR) with the PI3K pathway. Tyrosine phosphorylation of BCAP by BCR-associated protein tyrosine kinases, such as Syk and Btk, generates binding sites for the p85 subunit of PI3K, resulting in activation of the PI3K pathway. Human and mouse BCAP contain 3 YXXM SH2 binding motifs for interaction with PI3K. BCAP null mice have deficient immune function, with B cells that exhibit enhanced apoptosis.

Gene Full Name: phosphoinositide-3-kinase adaptor protein 1

Gen-ID: 118788

UniProt: Q6ZUJ8

Pathways: Activation of Innate immune Response, BCR Signaling, Warburg Effekt