Cyclin D3 Antikörper (AA 136-292) (HRP)

Produktnummer ABIN7982193

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Cyclin D3 in WB, IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für Cyclin D3 Antikörper (AA 136-292) (HRP) (ABIN7982193)

Target: Cyclin D3 (CCND3)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin D3 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Cyclin D3 Antikörper (HRP)

Bindungsspezifität: AA 136-292

Verwendungszweck: Anti-Cyclin D3/CCND3 Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human Cyclin D3 shares 94%,93% amino acid (aa) sequences identity with mouse,rat Cyclin D3,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Cyclin D3 recombinant protein (Position: Q136-L292). Human Cyclin D3 shares 94% and 93% amino acid (aa) sequences identity with mouse and rat Cyclin D3, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Cyclin D3

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: CCND3

Hintergrund:

Background: CCND3, also called Cyclin D3, is a protein that in humans is encoded by the CCND3 gene. It is mapped to 6p21.1. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. In addition, overexpression of CCND3 upregulated the translational activity in HeLa cells in a dose-dependent manner.

Gene Full Name: cyclin D3

Sequence Similarities: Belongs to the cyclin family. Cyclin D subfamily.

Gen-ID: 896

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process