Cyclin A1 Antikörper (AA 64-263) (FITC)

Produktnummer ABIN7982104

Der Kaninchen Polyklonal anti-Cyclin A1 Antikörper wird verwendet zum Nachweis von Cyclin A1 in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für Cyclin A1 Antikörper (AA 64-263) (FITC) (ABIN7982104)

Target: Cyclin A1 (CCNA1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin A1 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Cyclin A1 Antikörper (FITC)

Bindungsspezifität: AA 64-263

Verwendungszweck: Anti-Cyclin A1/CCNA1 Antibody FITC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human Cyclin A1 shares 78.5%,79.5% amino acid (aa) sequence identity with mouse,rat Cyclin A1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Cyclin A1 recombinant protein (Position: D64-E263). Human Cyclin A1 shares 78.5% and 79.5% amino acid (aa) sequence identity with mouse and rat Cyclin A1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu Cyclin A1

Target: Cyclin A1 (CCNA1)

Andere Bezeichnung: CCNA1

Hintergrund:

Background: Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Also this cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: cyclin A1

Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.

Gen-ID: 8900

UniProt: P78396

Pathways: Apoptose, Zellzyklus, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA