KDM5B Antikörper

Produktnummer ABIN7938291

Der Kaninchen Polyklonal anti-KDM5B Antikörper (ABIN7938291) detektiert spezifisch KDM5B in ChIP. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für KDM5B Antikörper (ABIN7938291)

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM5B Antikörper ist unkonjugiert

Applikation: Chromatin Immunoprecipitation (ChIP)

Produktdetails anti-KDM5B Antikörper

Verwendungszweck: JARID1B / KDM5B antibody (pAb)

Aufreinigung: Protein A Chromatography

Immunogen: This antibody was raised against a human peptide belonging to demethyase JARID1B.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ChIP-Seq: 10 µL each

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS, 30 % glycerol, 0.035 % Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu KDM5B

Target: KDM5B (Lysine (K)-Specific Demethylase 5B (KDM5B))

Andere Bezeichnung: JARID1B

Hintergrund:

Background_Plain: Lysine (K)-specific demethylase 5B (KDM5B), also known as Jumonji, AT rich interactive domain 1B (JARID1B), is a histone demethylase that specifically demethylates lysine 4 of histone H3 (H3K4), thereby playing a central role in defining the histone code. KDM5B demethylates trimethylated, dimethylated and monomethylated H3K4. It does not demethylate histone H3K9 or H3K27. KDM5B functions as a transcriptional corepressor for FOXG1B and PAX9. KDM5B induces the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, it may act as a tumor suppressor for melanoma.

Aliases: Lysine Demethylase 5B, lysine (K)-specific demethylase 5B

Molekulargewicht: 180 kDa

NCBI Accession: NP_006609

Pathways: Warburg Effekt