Retinoblastoma Binding Protein 8 Antikörper (AA 620-897)

Produktnummer ABIN7938099

Der Maus Monoklonal anti-Retinoblastoma Binding Protein 8 Antikörper (Klon 14-1) (ABIN7938099) detektiert spezifisch Retinoblastoma Binding Protein 8 in WB, IP, IF, ICC und ChIP. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Retinoblastoma Binding Protein 8 Antikörper (AA 620-897) (ABIN7938099)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoblastoma Binding Protein 8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP)

Klon: 14-1

Produktdetails anti-Retinoblastoma Binding Protein 8 Antikörper

Bindungsspezifität: AA 620-897

Verwendungszweck: CtIP antibody (mAb) (Clone 14-1)

Aufreinigung: Protein A Chromatography

Immunogen: This CtIP antibody was raised against a recombinant protein corresponding to amino acid residues 620-897 of human CtIP.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1 - 2 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Andere Bezeichnung: CtIP

Hintergrund:

Background_Plain: CtIP (CTBP interacting protein, RBBP8, RIM, COM1) is a transcriptional regulator and tumor suppressor first identified through its interaction with CTBP (C-Terminal Binding Protein). CtIP binds to the Rb protein and serves as a transcriptional repressor, through recruitment of CtBP and also by interaction with general transcription factors TFIID and TFIIB. CtIP also interacts with Rb-related protein p130 and Ikaros, a master regulator in lymphocyte development. CtIP is phosphorylated upon DNA damage (likely by ATM and/or ATR), interacts with BRCA1 and plays a critical role in facilitating DNA damage repair. Mutations that abolish the interaction between CtIP and BRCA1 result in loss of cell cycle control leading to the development of cancer.

Aliases: RBBP8, RIM, COM1, JWDS, SAE2, SCKL2

Molekulargewicht: 120 kDa

NCBI Accession: NP_002885

Pathways: Zellzyklus, DNA Reparatur