Rekombinanter LYN Antikörper

Produktnummer ABIN7882654

Der Kaninchen Monoklonal anti-LYN Antikörper wird verwendet zum Nachweis von LYN in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für Rekombinanter LYN Antikörper (ABIN7882654)

Target: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser LYN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 32L39

Produktdetails anti-LYN Antikörper

Verwendungszweck: LYN Antibody / Tyrosine-protein kinase Lyn

Aufreinigung: Affinity chromatography

Immunogen: A synthesized peptide derived from human Lyn protein was used as the immunogen for the LYN antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the LYN antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the LYN antibody at -20oC.

Details zu LYN

Target: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Andere Bezeichnung: LYN

Hintergrund: LYN antibody detects Tyrosine-protein kinase Lyn, encoded by the LYN gene. Tyrosine-protein kinase Lyn is a member of the Src family of non-receptor tyrosine kinases and is widely expressed in hematopoietic cells, where it plays essential roles in immune receptor signaling, proliferation, differentiation, and apoptosis. LYN antibody provides researchers with a specific reagent for studying signaling networks that govern immune cell activation and cancer biology.

Tyrosine-protein kinase Lyn functions downstream of antigen and cytokine receptors, phosphorylating immunoreceptor tyrosine-based activation and inhibition motifs. Research using LYN antibody has shown that it can both activate and inhibit signaling depending on context, making it a key modulator of immune responses. Lyn phosphorylates substrates such as SYK, PI3K, and SHP phosphatases, coordinating positive and negative feedback loops. This dual regulatory role highlights its importance in immune tolerance and activation balance.

Studies with LYN antibody have revealed its role in B cell receptor signaling. Tyrosine-protein kinase Lyn initiates signaling by phosphorylating immunoreceptor tyrosine-based activation motifs, recruiting downstream effectors that drive calcium flux, gene transcription, and survival. At the same time, it phosphorylates inhibitory motifs that recruit phosphatases to limit signaling intensity. This balance prevents inappropriate activation while allowing robust responses to pathogens.

Dysregulation of Lyn contributes to disease. Research using LYN antibody has demonstrated that overactive Lyn signaling is implicated in chronic myeloid leukemia and B cell malignancies, where it enhances survival and proliferation. Conversely, deficiency or loss of Lyn function contributes to autoimmune disorders by impairing inhibitory signaling. These findings establish Lyn as a therapeutic target in both cancer and autoimmunity.

Lyn also participates in platelet activation, mast cell degranulation, and macrophage responses, emphasizing its broad roles in hematopoietic physiology. Beyond immune function, Lyn contributes to epithelial and neuronal signaling, expanding its relevance to non-hematopoietic systems. These functions highlight the versatility of Tyrosine-protein kinase Lyn as a signaling hub.

LYN antibody is widely used in western blotting, immunohistochemistry, and immunoprecipitation. Western blotting detects total protein levels and phosphorylation states, immunohistochemistry reveals expression in lymphoid organs, and immunoprecipitation enables mapping of protein complexes. These applications make LYN antibody essential for signaling research.

By supplying validated LYN antibody reagents, NSJ Bioreagents supports studies into immune regulation, oncology, and signal transduction. Detection of Tyrosine-protein kinase Lyn provides researchers with insights into how Src family kinases integrate activating and inhibitory signals.

UniProt: P07948

Pathways: Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling