SQSTM1 Antikörper

Produktnummer ABIN7882237

Der Maus Monoklonal anti-SQSTM1 Antikörper wird verwendet zum Nachweis von SQSTM1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF, FACS und IHC (p).

Kurzübersicht für SQSTM1 Antikörper (ABIN7882237)

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SQSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 3H11

Produktdetails anti-SQSTM1 Antikörper

Verwendungszweck: SQSTM1 Antibody / p62

Sequenz: DEDGDLVAFS SDEELTMAMS YVKDDIFR

Aufreinigung: Affinity purified

Immunogen: Amino acids DEDGDLVAFSSDEELTMAMSYVKDDIFR were used as the immunogen for the SQSTM1 antibody.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SQSTM1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SQSTM1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SQSTM1

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Andere Bezeichnung: SQSTM1

Hintergrund: SQSTM1 (Sequestosome-1), also known as Ubiquitin-Binding Protein P62 or P62, is a protein that in humans is encoded by the SQSTM1 gene. The Src homology type 2 (SH2) domain is a highly conserved motif of about 100 amino acids which mediates protein-protein interactions by binding to phosphotyrosine.p56-lck, a T-cell-specific src family tyrosine kinase with an SH2 domain, is involved in T-cell signal transduction. The International Radiation Hybrid Mapping Consortium mapped the p62 gene to chromosome 5q35. Park et al. (1995) found that the p56-lck SH2 domain binds to p62 at the ser59 of p62 only when that serine is phosphorylated. Joung et al. (1996) expressed epitope-tagged p62 in Hela cells and showed that the expressed protein bound to the lck SH2 domain and that this binding was dependent on the N-terminal 50 amino acids of p62 but not on the tyrosine residue in this region.

UniProt: Q13501

Pathways: NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie