Rekombinanter Caspase 6 Antikörper

Produktnummer ABIN7880193

Der Kaninchen Monoklonal anti-Caspase 6 Antikörper wird verwendet zum Nachweis von Caspase 6 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter Caspase 6 Antikörper (ABIN7880193)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Caspase 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 31C93

Produktdetails anti-Caspase 6 Antikörper

Verwendungszweck: CASP6 Antibody / Caspase 6

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Caspase-6 was used as the immunogen for the CASP6 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the CASP6 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the CASP6 antibody at -20oC.

Details zu Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Andere Bezeichnung: CASP6

Hintergrund: CASP6 antibody detects caspase 6, a cysteine protease encoded by the CASP6 gene. Alternate identifiers include MCH2 and apoptotic cysteine protease 6. Caspase 6 belongs to the caspase family of cysteine aspartate proteases that orchestrate apoptosis and inflammation. Synthesized as an inactive proenzyme, caspase 6 undergoes autocatalytic processing or cleavage by upstream caspases to generate the active enzyme, which then cleaves specific substrates during programmed cell death.

CASP6 antibody is widely applied in neuroscience, apoptosis research, and oncology. Caspase 6 activity contributes to neuronal apoptosis and axonal degeneration, with elevated activity linked to Alzheimer disease and Huntington disease. In cancer biology, caspase 6 mediates apoptosis in response to stress and chemotherapeutic drugs. By detecting caspase 6, researchers can examine apoptotic pathways and their dysregulation in disease.

Western blot assays identify pro and cleaved caspase 6 isoforms, immunohistochemistry maps expression in tissues undergoing apoptosis, and immunofluorescence detects localization in neuronal and cancer cell models. These assays provide robust methods for analyzing apoptotic signaling pathways.

Caspase 6 cleaves substrates such as lamin A and huntingtin, contributing to nuclear disassembly and neurodegeneration. Dysregulated activity promotes pathological cell death, while insufficient activity may contribute to impaired apoptosis in cancer. By applying CASP6 antibody, scientists can evaluate the balance of pro survival and pro death signals across systems.

CASP6 antibody from NSJ Bioreagents delivers reliable specificity for detecting caspase 6. Its performance across multiple applications supports both basic apoptosis research and translational studies in oncology and neurodegeneration.

UniProt: P55212

Pathways: Apoptose, Caspase Kaskade in der Apoptose