MECP2 Antikörper (pSer423)

Produktnummer ABIN7879743

Der Kaninchen Polyklonal anti-MECP2 Antikörper wird verwendet zum Nachweis von MECP2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC (p).

Kurzübersicht für MECP2 Antikörper (pSer423) (ABIN7879743)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MECP2 Antikörper

Bindungsspezifität: pSer423

Verwendungszweck: Phospho-MeCP2 Antibody (pS423)

Aufreinigung: Antigen affinity purified

Immunogen: A synthetic peptide corresponding the amino acids surrounding phosphorylated S423 was used as the immunogen for the phospho-MeCP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the phospho-MeCP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the phospho-MeCP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu MECP2

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MeCP2

Hintergrund: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane