CD42a Antikörper (Middle Region)

Produktnummer ABIN7879522

Der Kaninchen Polyklonal anti-CD42a Antikörper (ABIN7879522) detektiert spezifisch CD42a in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für CD42a Antikörper (Middle Region) (ABIN7879522)

Target: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD42a Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-CD42a Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Glycoprotein 9 Antibody / Gp9 / CD42a

Aufreinigung: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CD42a/GP9 was used as the immunogen for the Glycoprotein 9 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Glycoprotein 9 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Glycoprotein 9 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CD42a

Target: CD42a (GP9) (Glycoprotein IX (Platelet) (GP9))

Andere Bezeichnung: Glycoprotein 9

Hintergrund: Glycoprotein 9 antibody detects Platelet glycoprotein IX, a membrane glycoprotein that forms part of the GPIb-IX-V complex essential for platelet adhesion and thrombus formation. Glycoprotein 9 functions as a structural subunit that stabilizes the GPIbalpha receptor, enabling platelet interaction with von Willebrand factor under high shear conditions. The Glycoprotein 9 antibody is widely used in hematology and cardiovascular research to study platelet function, coagulation, and bleeding disorders.

The protein is encoded by the GP9 gene on human chromosome 3q21.3. Glycoprotein 9 is approximately 177 amino acids long and contains a single leucine-rich repeat flanked by cysteine-rich regions, which maintain receptor conformation and complex assembly. It is expressed exclusively on platelet membranes and megakaryocytes, where it associates non-covalently with GPIbalpha and GPIbbeta to form the functional receptor complex for von Willebrand factor binding.

The Glycoprotein 9 antibody detects a 25 kilodalton band by western blot and shows strong membrane staining in platelets. The GPIb-IX-V complex mediates platelet tethering to exposed subendothelial matrix at sites of vascular injury, initiating platelet activation and aggregation. Defects or mutations in Glycoprotein 9 lead to Bernard-Soulier syndrome, characterized by thrombocytopenia, giant platelets, and impaired adhesion.

Beyond hemostasis, the GPIb-IX-V complex participates in inflammatory and immune signaling. Platelet Glycoprotein 9 contributes to leukocyte recruitment, vascular permeability, and thromboinflammatory responses. Overexpression or dysregulation has been associated with thrombosis and cardiovascular disease, making it an important target for antithrombotic therapy.

Because of its role in platelet adhesion and vascular integrity, Glycoprotein 9 is a critical biomarker for platelet-related disorders. NSJ Bioreagents provides a validated Glycoprotein 9 antibody optimized for its applications, supporting research into hemostasis, thrombosis, and vascular inflammation.

UniProt: P14770