PLK1 Antikörper (full length)

Produktnummer ABIN7878823

Der Maus Monoklonal anti-PLK1 Antikörper (Klon AZ44) (ABIN7878823) detektiert spezifisch PLK1 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Xenopus laevis.

Kurzübersicht für PLK1 Antikörper (full length) (ABIN7878823)

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Reaktivität: Xenopus laevis

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PLK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Güteklasse: Carrier-free

Klon: AZ44

Produktdetails anti-PLK1 Antikörper

Bindungsspezifität: full length

Verwendungszweck: PLK1 Antibody / Polo-Like Kinase 1 (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: Recombinant Xenopus laevis full length protein was used as the immunogen for the PLK1 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PLK1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the PLK1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu PLK1

Target: PLK1 (Polo-Like Kinase 1 (PLK1))

Andere Bezeichnung: PLK1

Hintergrund: Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and Cdc5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Useful for confirming that extracts have maintained CSF status and have not yet been activated into interphase.

UniProt: P70032

Pathways: Zellzyklus, M Phase