PLK1 Antikörper (AA 86-430)
Kurzübersicht für PLK1 Antikörper (AA 86-430) (ABIN7876998)
Target
Alle PLK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 86-430
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Verwendungszweck
- PLK1 Antibody
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Aufreinigung
- Affinity purified
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Immunogen
- A human recombinant protein (amino acids K86-N430) was used as the immunogen for the PLK1 antibody.
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Isotyp
- IgG2b
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Applikationshinweise
- Optimal dilution of the PLK1 antibody should be determined by the researcher.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- After reconstitution, the PLK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PLK1 (Polo-Like Kinase 1 (PLK1))
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Andere Bezeichnung
- PLK1
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Hintergrund
- Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase1) gene. Plk1 is an early trigger for G2/M transition. It supports the functional maturation of the centrosome in late G2/early prophase and establishment of the bipolar spindle. Also, Plk1 phosphorylates and activates cdc25C, a phosphatase that dephosphorylates and activates the cyclinB/cdc2 complex. Studies have shown that the loss of PLK1 expression can induce pro-apoptotic pathways and inhibit growth. Based on yeast and murine studies of meiosis, human PLK1 may also have a regulatory function in meiosis.
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UniProt
- P53350
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Pathways
- Zellzyklus, M Phase
Target
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