Rekombinanter GZMB Antikörper (AA 73-187)

Produktnummer ABIN7876652

Dieser Maus Monoklonal Antikörper detektiert spezifisch GZMB in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter GZMB Antikörper (AA 73-187) (ABIN7876652)

Target: GZMB (Granzyme B (GZMB))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GZMB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: RGZMB-4538

Produktdetails anti-GZMB Antikörper

Bindungsspezifität: AA 73-187

Verwendungszweck: Recombinant GZMB Antibody / Granzyme B (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 73-187 was used as the immunogen for the recombinant GZMB antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant GZMB antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant GZMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Andere Bezeichnung: GZMB

Hintergrund: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

UniProt: P10144

Pathways: Apoptose, Caspase Kaskade in der Apoptose