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GZMB Antikörper (Granzyme B) Primary Antibody

GZMB Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal CLB-GB11 unconjugated
Pubmed (3 references)
Produktnummer ABIN1302451
$400.75
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle GZMB Antikörper anzeigen
    GZMB
    Reaktivität
    • 128
    • 53
    • 26
    • 12
    • 4
    • 3
    • 1
    • 1
    Human, Non-Human Primate
    Wirt
    • 86
    • 42
    • 2
    Maus
    Klonalität
    • 85
    • 45
    Monoklonal
    Konjugat
    • 80
    • 13
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GZMB Antikörper ist unkonjugiert
    Applikation
    • 64
    • 48
    • 42
    • 42
    • 21
    • 20
    • 18
    • 13
    • 13
    • 9
    • 8
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed in activated Tc cells and NK cells.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified by protein-A affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Human NK cell line YT-INDY-derived granzyme B
    Klon
    CLB-GB11
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Rissoan, Duhen, Bridon, Bendriss-Vermare, Péronne, de Saint Vis, Brière, Bates: "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells." in: Blood, Vol. 100, Issue 9, pp. 3295-303, (2002) (PubMed).

    Tak, Spaeny-Dekking, Kraan, Breedveld, Froelich, Hack: "The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)." in: Clinical and experimental immunology, Vol. 116, Issue 2, pp. 366-70, (1999) (PubMed).

    Spaeny-Dekking, Hanna, Wolbink, Wever, Kummer, Kummer, Swaak, Middeldorp, Huisman, Froelich, Hack: "Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3610-6, (1998) (PubMed).

  • Target
    GZMB
    Andere Bezeichnung
    Granzyme B (GZMB Produkte)
    Synonyme
    CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, GZMB
    Hintergrund
    Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose
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