Rekombinanter GZMB Antikörper (AA 73-187)

Produktnummer ABIN7876651

Der Kaninchen Monoklonal anti-GZMB Antikörper (Klon GZMB-4539R) (ABIN7876651) detektiert spezifisch GZMB in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter GZMB Antikörper (AA 73-187) (ABIN7876651)

Target: GZMB (Granzyme B (GZMB))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser GZMB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: GZMB-4539R

Produktdetails anti-GZMB Antikörper

Bindungsspezifität: AA 73-187

Verwendungszweck: Recombinant Granzyme B Antibody

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 73-187 was used as the immunogen for the recombinant Granzyme B antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Granzyme B antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the recombinant Granzyme B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu GZMB

Target: GZMB (Granzyme B (GZMB))

Andere Bezeichnung: Granzyme B

Hintergrund: Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.

UniProt: P10144

Pathways: Apoptose, Caspase Kaskade in der Apoptose