ERK1 Antikörper (pThr197, pThr202)

Produktnummer ABIN744143

Der Kaninchen Polyklonal Anti-ERK1-Antikörper wurde für WB, ELISA, IHC (p), IF (p), IF (cc) und IHC (fro) validiert. Er ist geeignet, ERK1 in Proben von Human, Maus und Schwein zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für ERK1 Antikörper (pThr197, pThr202) (ABIN744143)

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Reaktivität: Human, Maus, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ERK1 Antikörper

Bindungsspezifität: pThr197, pThr202

Kreuzreaktivität: Human, Maus, Schwein

Homologie: Rat,Dog,Cow,Horse,Chicken,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human ERK1 around the phosphorylation site of Thr197/Thr202

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-ERK1 Antikörper (ABIN744143)

Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).

Chu, Zhao, Feng, Zhang, Liu, Cheng, Li, Shen, Cao, Li, Min: "MicroRNA-126 participates in lipid metabolism in mammary epithelial cells." in: Molecular and cellular endocrinology, Vol. 454, pp. 77-86, (2017) (PubMed).

Qu, Wu, Wu, Ji, Qiang, Jiang, Jiang, Ding: "Exosomal miR-665 as a novel minimally invasive biomarker for hepatocellular carcinoma diagnosis and prognosis." in: Oncotarget, Vol. 8, Issue 46, pp. 80666-80678, (2017) (PubMed).

Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." in: Scientific reports, Vol. 6, pp. 37884, (2016) (PubMed).

Details zu ERK1

Target: ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))

Andere Bezeichnung: ERK1 +

Hintergrund:

Synonyms: ERK 1, ERK 2, ERK-2, ERK1, ERK2, ERT1, ERT2, Extracellular signal regulated kinase 1, Extracellular signal regulated kinase 1, Extracellular signal regulated kinase 2, Extracellular signal regulated kinase 2, Extracellular signal-regulated kinase 2, HS44KDAP, HUMKER1A, Insulin stimulated MAP2 kinase, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAP kinase isoform p44, MAPK 1, MAPK 2, MAPK1, MAPK2, MGC20180, Microtubule associated protein 2 kinase, Mitogen activated protein kinase 1, Mitogen activated protein kinase 1, Mitogen activated protein kinase 2, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, MK01_MOUSE, p38, p40, p41, p41mapk, p42 MAPK, p42-MAPK, p42MAPK, p42MAPK, p44 ERK1, p44 MAPK, p44ERK1, p44ERK1, p44MAPK, p44MAPK, PRKM 1, PRKM 1, PRKM 2, PRKM 2, PRKM1, PRKM2, Protein kinase mitogen activated 1, Protein kinase mitogen activated 1, Protein kinase mitogen activated 2, Protein kinase mitogen activated 2, Protein tyrosine kinas.

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Gen-ID: 5595

Pathways: MAPK Signalweg, RTK Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteine