PIK3CD Antikörper (AA 520-720)

Produktnummer ABIN7875579

Der Maus Monoklonal anti-PIK3CD Antikörper wird verwendet zum Nachweis von PIK3CD in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für PIK3CD Antikörper (AA 520-720) (ABIN7875579)

Target: PIK3CD (Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide (PIK3CD))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIK3CD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: PIK3CD-4639

Produktdetails anti-PIK3CD Antikörper

Bindungsspezifität: AA 520-720

Verwendungszweck: PIK3CD Antibody / p110delta

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment of human PIK3CD protein (within amino acids 520-720) was used as the immunogen for the PIK3CD antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the PIK3CD antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the PIK3CD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu PIK3CD

Target: PIK3CD (Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide (PIK3CD))

Andere Bezeichnung: PIK3CD

Hintergrund: Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85a and p85b), each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110a and p110b interact with p85a, and p110a has also been shown to interact with p85b in vitro. It has been shown to bind p85a and b, but it apparently does not phosphorylate these subunits. p110d has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly, p110g does not interact with the p85 subunits and has been shown to be activated by a and bg heterotrimeric G proteins. Two p110d isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus, lung and spleen tissues.

UniProt: O00329

Pathways: BCR Signaling, Warburg Effekt