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PIK3CD Antikörper (AA 51-150)

PIK3CD Reaktivität: Human, Maus WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2178450
  • Target Alle PIK3CD Antikörper anzeigen
    PIK3CD (Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide (PIK3CD))
    Bindungsspezifität
    • 23
    • 14
    • 12
    • 10
    • 9
    • 8
    • 8
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reaktivität
    • 108
    • 43
    • 10
    Human, Maus
    Wirt
    • 103
    • 7
    Kaninchen
    Klonalität
    • 95
    • 15
    Polyklonal
    Konjugat
    • 38
    • 10
    • 9
    • 9
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PIK3CD Antikörper ist unkonjugiert
    Applikation
    • 79
    • 58
    • 40
    • 25
    • 25
    • 17
    • 14
    • 8
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PI3 Kinase p110 delta
    Isotyp
    IgG
    Top Product
    Discover our top product PIK3CD Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PIK3CD (Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide (PIK3CD))
    Andere Bezeichnung
    PI3 Kinase p110 delta (PIK3CD Produkte)
    Synonyme
    2410099E07Rik antikoerper, 2610208K16Rik antikoerper, AW545373 antikoerper, p110delta antikoerper, P110DELTA antikoerper, PI3K antikoerper, p110D antikoerper, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta antikoerper, Pik3cd antikoerper, PIK3CD antikoerper
    Hintergrund

    Synonyms: p110D, p110delta, Phosphatidylinositol 3 kinase catalytic delta polypeptide, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform, Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform,

    Background: Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration.

    Gen-ID
    5293
    Pathways
    BCR Signaling, Warburg Effekt
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