CDK8 Antikörper (AA 355-464)

Produktnummer ABIN7874261

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CDK8 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CDK8 Antikörper (AA 355-464) (ABIN7874261)

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDK8 Antikörper

Bindungsspezifität: AA 355-464

Verwendungszweck: CDK8 Antibody

Aufreinigung: Antigen affinity

Immunogen: An amino acids 355-464 from the human protein were used as the immunogen for this CDK8 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the CDK8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the CDK8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu CDK8

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: CDK8

Hintergrund: Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene. It is mapped to 13q12.13. This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

UniProt: P49336

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha