Rekombinanter AMACR Antikörper (AA 297-394)

Produktnummer ABIN7873469

Dieser Maus Monoklonal Antikörper detektiert spezifisch AMACR in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter AMACR Antikörper (AA 297-394) (ABIN7873469)

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AMACR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RAMACR-1864

Produktdetails anti-AMACR Antikörper

Bindungsspezifität: AA 297-394

Verwendungszweck: Recombinant AMACR/p504S Antibody

Aufreinigung: Protein G affinity chromatography

Immunogen: A human recombinant partial protein (amino acids 297-394) was used as the immunogen for the recombinant AMACR/p504S antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant AMACR/p504S antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant AMACR/p504S antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu AMACR

Target: AMACR (alpha-Methylacyl-CoA Racemase (AMACR))

Andere Bezeichnung: AMACR/p504S

Hintergrund: AMACR/p504S antibody is used to study Alpha-methylacyl-CoA racemase, a peroxisomal and mitochondrial enzyme involved in the beta-oxidation of branched-chain fatty acids and bile acid intermediates. Alpha-methylacyl-CoA racemase is encoded by the AMACR gene and catalyzes the interconversion of R- and S-stereoisomers of alpha-methyl-branched acyl-CoA substrates, a necessary step for their subsequent degradation through beta-oxidation pathways. This enzymatic activity links AMACR to lipid metabolism and energy homeostasis in metabolically active tissues.

Alpha-methylacyl-CoA racemase is widely known as p504S, a designation that originated from early gene expression studies identifying strong upregulation of this protein in prostate carcinoma. The p504S antigen became an important marker for distinguishing malignant prostate epithelium from benign glands, leading to extensive use of AMACR/p504S antibody in studies of prostate cancer biology and diagnostic marker evaluation. Use of an AMACR/p504S antibody enables investigation of this cancer-associated expression pattern in tissue and cell-based research models.

At the subcellular level, Alpha-methylacyl-CoA racemase localizes primarily to the cytoplasm, with enrichment in peroxisomes and mitochondria, reflecting its role in fatty acid metabolism. This localization supports metabolic processing of branched-chain lipids derived from dietary sources and bile acid synthesis. Studies using AMACR antibody have helped define its compartmentalized activity and its contribution to lipid catabolism in epithelial and metabolic tissues.

Beyond prostate cancer, altered expression of Alpha-methylacyl-CoA racemase has been reported in additional malignancies, including renal cell carcinoma, hepatocellular carcinoma, and colorectal cancer, suggesting broader relevance in tumor-associated metabolic reprogramming. Elevated AMACR expression is thought to reflect increased reliance on lipid metabolism pathways in proliferating tumor cells. Detection of AMACR using an AMACR/p504S antibody supports research into metabolic adaptation, tumor progression, and lipid utilization in cancer biology.

AMACR/p504S antibody (clone rAMACR/1864) is designed to detect Alpha-methylacyl-CoA racemase in research applications. Analysis of AMACR expression provides insight into fatty acid metabolism, peroxisomal and mitochondrial function, and disease-associated metabolic changes. Alpha-methylacyl-CoA racemase remains a key enzyme for studies examining the intersection of lipid metabolism and cancer-associated metabolic remodeling.

UniProt: Q9UHK6

Pathways: Monocarboxylic Acid Catabolic Process