BCL10 Antikörper (AA 24-51)

Produktnummer ABIN7872699

Der Kaninchen Polyklonal anti-BCL10 Antikörper wird verwendet zum Nachweis von BCL10 in Proben von Human und Maus. Er wurde validiert für WB, IF, FACS und IHC (p).

Kurzübersicht für BCL10 Antikörper (AA 24-51) (ABIN7872699)

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BCL10 Antikörper

Bindungsspezifität: AA 24-51

Verwendungszweck: BCL10 Antibody

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 24-51 from the human protein was used as the immunogen for the BCL10 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the BCL10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the BCL10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Andere Bezeichnung: BCL10

Hintergrund: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

UniProt: O95999

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine