SOS1 Antikörper (AA 177-1288)

Produktnummer ABIN7871341

Der Kaninchen Polyklonal anti-SOS1 Antikörper (ABIN7871341) detektiert spezifisch SOS1 in WB, ELISA, IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für SOS1 Antikörper (AA 177-1288) (ABIN7871341)

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SOS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-SOS1 Antikörper

Bindungsspezifität: AA 177-1288

Verwendungszweck: SOS1 Antibody / Son of sevenless 1

Aufreinigung: Immunogen affinity purified

Immunogen: E.coli-derived human SOS1 recombinant protein (Position: H177-A1288) was used as the immunogen for the SOS1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the SOS1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the SOS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu SOS1

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Andere Bezeichnung: SOS1

Hintergrund: SOS1 antibody detects Son of sevenless homolog 1, a guanine nucleotide exchange factor (GEF) that activates Ras and Rac GTPases, serving as a critical link between receptor tyrosine kinases and downstream signaling cascades. SOS1 catalyzes the exchange of GDP for GTP on Ras, thereby triggering MAPK and PI3K pathway activation. The SOS1 antibody is widely used in cell signaling, oncology, and developmental biology to study Ras-mediated signal transduction and growth control.

SOS1 is encoded by the SOS1 gene on human chromosome 2p22.1. The protein is approximately 1333 amino acids long and consists of several domains: an N-terminal histone-like fold, a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, and a C-terminal catalytic region responsible for Ras activation. SOS1 is recruited to the plasma membrane through interaction with adaptor proteins such as GRB2 following growth factor stimulation.

The SOS1 antibody detects a 155 kilodalton protein in western blot assays and shows cytoplasmic and membrane localization by immunofluorescence. Upon receptor activation, SOS1 facilitates Ras activation at the plasma membrane, leading to phosphorylation of ERK and other downstream targets. Through its DH-PH domains, SOS1 also activates Rac, linking actin cytoskeleton remodeling to growth factor signaling.

SOS1 plays essential roles in development, cell proliferation, and differentiation. Germline mutations in SOS1 cause Noonan syndrome, a developmental disorder characterized by short stature and congenital heart defects. In cancer, overexpression or dysregulation of SOS1 contributes to aberrant Ras activation and uncontrolled growth signaling. Its activity is finely tuned by feedback loops involving phosphorylation, ubiquitination, and membrane recruitment dynamics.

Because of its central position in the Ras signaling cascade, SOS1 is a valuable target for understanding receptor-driven proliferation and oncogenic transformation. NSJ Bioreagents provides a validated SOS1 antibody optimized for its applications, supporting research into Ras activation, MAPK pathway signaling, and cell differentiation control.

UniProt: Q07889

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling