APC Antikörper (AA 1-433)

Produktnummer ABIN7869356

Dieser Maus Monoklonal Antikörper detektiert spezifisch APC in WB, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für APC Antikörper (AA 1-433) (ABIN7869356)

Target: APC (Adenomatous Polyposis Coli (APC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: ALi 12-28

Produktdetails anti-APC Antikörper

Bindungsspezifität: AA 1-433

Verwendungszweck: Adenomatous polyposis coli Antibody / APC (azide and preservative free)

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 1-433) was used as the immunogen for the Adenomatous polyposis coli antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Adenomatous polyposis coli antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the Adenomatous polyposis coli antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: Adenomatous polyposis coli

Hintergrund: The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. Functions as a tumor suppressor, promoting rapid degradation of CTNNB1 and is a negative regulator of Wnt signaling. Also plays a role in HGF-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization