APC Antikörper (AA 1-50)

Produktnummer ABIN7448412

Der Kaninchen Polyklonal anti-APC Antikörper (ABIN7448412) detektiert spezifisch APC in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für APC Antikörper (AA 1-50) (ABIN7448412)

Target: APC (Adenomatous Polyposis Coli (APC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-APC Antikörper

Bindungsspezifität: AA 1-50

Verwendungszweck: Rabbit anti-APC IHC Antibody, affinity purified

Homologie: Mouse,Rat,Zebrafish,X. tropicalis,Chicken,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Monkey,Gorilla,Chimpanzee,Duckbill platypus,Crab-eating macaque,African elephant,Little brown bat,Zebra finch,Small-eared galago,Gray short-tailed opossum,White-tufted-ear marmoset,Tasmanian devil,Northern white-cheeked gibbon,Naked mole rat

Aufreinigung: Affinity Purified

Immunogen: Between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: APC

Hintergrund: Background: Adenomatosis polyposis coli (APC) is a tumor suppressor gene found to be mutated in most colon cancers and is the cause of familial adenomatous polyposis (FAP), an autosomal dominant disease that results in a predisposition to malignant colon cancer. APC has been shown to be involved in cell differentiation, migration, proliferation and adhesion. One function of APC involves its role as a scaffolding protein that regulates the phosphorylation and degradation of beta-catenin, a transcriptional regulator in the WNT signaling pathway. Additionally, APC has been found to be important in the regulation of microtubule arrays and mitotic spindle formation.

Gen-ID: 324

NCBI Accession: NP_000029

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization