MYD88 Antikörper (AA 1-266)

Produktnummer ABIN7869005

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MYD88 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für MYD88 Antikörper (AA 1-266) (ABIN7869005)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYD88 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MYD88 Antikörper

Bindungsspezifität: AA 1-266

Verwendungszweck: Zebrafish Myd88 Antibody

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Myd88 recombinant protein (amino acids M1-K266) was used as the immunogen for the Zebrafish Myd88 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Zebrafish Myd88 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Zebrafish Myd88 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Andere Bezeichnung: Myd88

Hintergrund: Myd88, or myeloid differentiation primary response protein 88, is an essential adaptor molecule in the innate immune system. In zebrafish, Myd88 mediates signal transduction from toll like receptors and interleukin one receptors, leading to activation of downstream inflammatory pathways that are critical for host defense.

Myd88 contains a death domain and a toll interleukin one receptor domain, which allow it to interact with both membrane bound receptors and cytoplasmic signaling proteins. Upon stimulation by pathogen associated molecular patterns such as bacterial lipopolysaccharide or viral RNA, toll like receptors recruit Myd88 to initiate signaling cascades that activate nuclear factor kappa B and mitogen activated protein kinases. This results in the production of proinflammatory cytokines and chemokines.

In zebrafish, Myd88 is maternally deposited and expressed throughout development, with increased expression in immune tissues such as the kidney and intestine. It plays a vital role in early immune responses to infection and has been extensively used in zebrafish models of inflammation, pathogen challenge, and immune signaling.

Loss of Myd88 function in zebrafish leads to impaired cytokine production and increased susceptibility to microbial infections, making it a valuable target for studies of innate immunity and inflammation. Due to its conservation across vertebrate species, zebrafish Myd88 is a widely used model for dissecting toll like receptor signaling and for testing immunomodulatory drugs.

UniProt: Q5XJ85

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades