IL-18 Antikörper (AA 1-193)

Produktnummer ABIN7868335

Der Maus Monoklonal anti-IL-18 Antikörper (Klon IL18-4623) (ABIN7868335) detektiert spezifisch IL-18 in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IL-18 Antikörper (AA 1-193) (ABIN7868335)

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: IL18-4623

Produktdetails anti-IL-18 Antikörper

Bindungsspezifität: AA 1-193

Verwendungszweck: Interleukin 18 Antibody / IL-18 (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant fragment (within amino acids 1-193) of human IL-18 protein was used as the immunogen for the Interleukin 18 antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Interleukin 18 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Interleukin 18 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Andere Bezeichnung: Interleukin 18

Hintergrund: Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1a, IL-1b and IL-1g/IL-18 and a specific receptor antagonist, IL-1Ra. IL-1a and IL-1b play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1g) has been shown to augment the secretion of IFN-g from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19 % and 12 % identity with IL-1a and IL-1b respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1b pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-g-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).

UniProt: Q14116

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome