BCL10 Antikörper (AA 122-168)
Kurzübersicht für BCL10 Antikörper (AA 122-168) (ABIN7865562)
Target
Alle BCL10 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
-
-
Bindungsspezifität
- AA 122-168
-
Verwendungszweck
- anti-BCL10 mouse monoclonal, EBS-T-001, purified
-
Aufreinigung
- affinity chromatography
-
Immunogen
- human BCL10 recombinant protein (aa122-168)
-
Isotyp
- IgG1 kappa
-
-
-
-
Applikationshinweise
-
IHC-paraffin_dilution: 1:50-1:100 (1-2 μg/mL, microwave treatment in 10 mM citrate buffer pH 6.0 recommended)
WB_dilution: 1:50-1:100 (1-2 μg/mL)
IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Konzentration
- 100 μg/mL
-
Buffer
- PBS with 0.02 % sodium azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Informationen zur Lagerung
- store at 2 - 8 °C
-
-
- BCL10 (B-Cell CLL/lymphoma 10 (BCL10))
-
Andere Bezeichnung
- BCL10
-
Hintergrund
- EBS-T-001 reacts with BCL10. Having an N-terminal caspase recruitment domain (CARD), BCL10 can induce apoptosis and activate NF-kappaB. It is found on subpopulations of normal B and T cells, and is associated with MALT1, a paracaspase that, like BCL10, can be found translocated in MALT lymphoma. In such cases either BCL10 or MALT1 or both are highly expressed, depending on the site of translocation. MALT lymphomas lacking this translocation exhibit much lower levels of expression. BCL10 has been shown to be functionally conserved all the way back to zebrafish. Positive control: HepG2 cells or lymphoma.
-
Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
Target
-