TCF7 Antikörper (AA 200-400)

Produktnummer ABIN7864523

Der Maus Monoklonal anti-TCF7 Antikörper wird verwendet zum Nachweis von TCF7 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für TCF7 Antikörper (AA 200-400) (ABIN7864523)

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TCF7 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TCF7-7631

Produktdetails anti-TCF7 Antikörper

Bindungsspezifität: AA 200-400

Verwendungszweck: TCF7 Antibody

Spezifität: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa200-400) of human TCF7 protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu TCF7

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Andere Bezeichnung: TCF7

Hintergrund:

Transcription Factor 7 (T-Cell Specific, HMG-Box), T-Cell-Specific Transcription Factor 1, T-Cell Factor 7

adrenal gland or colon.|Human spleen|lung

Molekulargewicht: 41.6kDa

Gen-ID: 6932, 573153

UniProt: P36402

Pathways: WNT Signalweg