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IRF7 Antikörper (pSer471, pSer472) (Biotin)

This anti-IRF7 antibody (ABIN742705) is a Rabbit Polyclonal antibody detecting IRF7 in WB, ELISA, IHC (p). Suitable for Human, Mouse, Rat.
Produktnummer ABIN742705

Kurzübersicht für IRF7 Antikörper (pSer471, pSer472) (Biotin) (ABIN742705)

Target

Alle IRF7 Antikörper anzeigen
IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reaktivität

  • 80
  • 56
  • 55
  • 17
  • 8
  • 3
  • 2
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 70
  • 11
Kaninchen

Klonalität

  • 58
  • 23
Polyklonal

Konjugat

  • 28
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser IRF7 Antikörper ist konjugiert mit Biotin

Applikation

  • 51
  • 21
  • 20
  • 14
  • 13
  • 13
  • 6
  • 6
  • 4
  • 3
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 15
    • 15
    • 15
    • 11
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer471, pSer472

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Cow,Pig,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    IRF7 (Interferon Regulatory Factor 7 (IRF7))

    Andere Bezeichnung

    IRF7 +

    Hintergrund

    Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7

    Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

    Gen-ID

    3665

    UniProt

    Q92985

    Pathways

    TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie
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