IL-18 Antikörper (AA 1-193)

Produktnummer ABIN7858334

Dieser Maus Monoklonal Antikörper detektiert spezifisch IL-18 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IL-18 Antikörper (AA 1-193) (ABIN7858334)

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: IL18-7781

Produktdetails anti-IL-18 Antikörper

Bindungsspezifität: AA 1-193

Verwendungszweck: IL-18 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody

Spezifität: Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1±, IL-1≤ and IL-1≥/IL-18 and a specific receptor antagonist, IL-1R±. IL-1± and IL-1≤ play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1≥) has been shown to augment the secretion of IFN-≥ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19 % and 12 % identity with IL-1± and IL-1≤ respectively over the 12 ≤-strands of the ≤-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1≤ pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-≥-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-193) of human IL-18 protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu IL-18

Target: IL-18 (IL18) (Interleukin 18 (IL18))

Andere Bezeichnung: IL-18

Hintergrund:

Iboctadekin, IFN gamma inducing factor, IGIF, IL1 gamma, IL18, IL18 protein, IL1F4, IL1g, IL1gamma, Interleukin 18, Interleukin-1 gamma, MGC12320

A549 cells, Human heart or adrenal gland. Stimulated peritoneal macrophages.

Molekulargewicht: 18kDa

Gen-ID: 3606, 83077

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome