Rekombinanter Glucagon Antikörper (AA 1-100)

Produktnummer ABIN7858106

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Glucagon in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Glucagon Antikörper (AA 1-100) (ABIN7858106)

Target: Glucagon (GCG)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Glucagon Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: GCG-13090R

Produktdetails anti-Glucagon Antikörper

Bindungsspezifität: AA 1-100

Verwendungszweck: Recombinant Glucagon (Marker of Glucagonoma) Antibody

Spezifität: Glucagon is a pancreatic hormone that functions as an antagonist to Insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the Glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas, of which approximately 80 % are malignant.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-100) of human GCG protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Glucagon

Target: Glucagon (GCG)

Andere Bezeichnung: Glucagon

Hintergrund:

GLP1, GLP2, GRPP, GLP-1

Human pancreas.

Molekulargewicht: 19kDa (Proglucagon), 3kDa (Glucagon)

Gen-ID: 2641

UniProt: P01275

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling