Rekombinanter Tyrosinase-Related Protein 1 Antikörper (C-Term)

Produktnummer ABIN7865490

Der Maus Monoklonal anti-Tyrosinase-Related Protein 1 Antikörper (Klon rG3E6) (ABIN7865490) detektiert spezifisch Tyrosinase-Related Protein 1 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Tyrosinase-Related Protein 1 Antikörper (C-Term) (ABIN7865490)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Tyrosinase-Related Protein 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: RG3E6

Produktdetails anti-Tyrosinase-Related Protein 1 Antikörper

Bindungsspezifität: C-Term

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody

Spezifität: Tyrosinase-related protein-1 (TRP-1) is a member of a family of proteins which are involved in melanin biosynthesis. The catalytic function of TRP-1 has not been fully resolved but the enzyme appears to be important in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid to form a high molecular weight pigmented biopolymer. In mammals, there are two basic types of melanin, the brown-black eumelanin and the reddish-yellow phaeomelanin. The concentrations of each are variable and are not related to skin type. In skin exposed to suberythemal doses of UVB, an increase in the number of melanocytes expressing TRP-1 and TRP-2 was observed with no increase noted in the number of tyrosinase-expressing melanocytes. In normal, untreated skin the number of melanocytes which immunohistochemically stain for either TRP-1, TRP-2 or tyrosinase appears to be similar irrespective of skin type. TRP-1 is also expressed in more than 50 per cent of choroidal melanocytes of the adult eye.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant fusion protein corresponding to the C-terminus of the TRP-1 molecule

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Andere Bezeichnung: Tyrosinase-Related Protein-1

Hintergrund:

5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75

SK-MEL-19, SK-MEL-23, SK-MEL-30 or SK-MEL-37 cells. Human Skin or Melanoma.

Molekulargewicht: 75kDa

Gen-ID: 7306, 270279

UniProt: P17643