Rekombinanter APC Antikörper (C-Term)

Produktnummer ABIN7857680

Dieser Maus Monoklonal Antikörper detektiert spezifisch APC in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter APC Antikörper (C-Term) (ABIN7857680)

Target: APC (Adenomatous Polyposis Coli (APC))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: REMM43

Produktdetails anti-APC Antikörper

Bindungsspezifität: C-Term

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor) Antibody

Spezifität: The human adenomatous polyposis coli (APC) gene at locus 5q21 encodes a protein of 2,843 amino acids. The precise function of this 300 kD protein is not clear but it may have several functions including a role in cell proliferation, apoptosis, expression of cell adhesion proteins and modulation of cell to cell interactions. It is reported to be expressed in the cytoplasm of cell types of many lineages, both epithelial and mesenchymal. In the epithelium of bladder, small and large intestine, esophagus, stomach and epidermis, APC expression is restricted to regions in which cell replication has ceased and terminal differentiation has been established. Expression has been observed in lung, liver, kidney and mammary gland endothelial, myoepithelial and duct lining epithelial cells. Some tissues such as ovary, myometrium, thyroid, parathyroid and tonsil do not express the protein.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein corresponding to a 251 amino acid region of the C-terminus of the human adenomatous polyposis coli protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: APC

Hintergrund:

Adenomatous Polyposis Coli, CC1, Deleted in polyposis 2.5 (DP2.5), DP2, DP3, FAP, FPC, GS, Protein APC

Human tonsil, placenta, breast or colon. HCT116 or COLO 320DM cells.

Molekulargewicht: 66kDa

Gen-ID: 324, 158932

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization