CD11b Antikörper (AA 520-570)

Produktnummer ABIN741285

Dieses Anti-CD11b-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD11b in FACS. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für CD11b Antikörper (AA 520-570) (ABIN741285)

Highlights:

• High quality CD11b Primärantikörper for the detection of ITGAM.
• Reliable product with high standard validation data

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD11b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Produktdetails anti-CD11b Antikörper

Bindungsspezifität: AA 520-570

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD11c

Isotyp: IgG

Produktspezifische Information:

What can the CD11b Antibody ABIN741285 be used for?: This polyclonal CD11b Antibody detects CD11b. The CD11b Antibody has been validated for various applications and can be used for the detection of CD11b and derivatives by Flow Cytometry.

What validation data is available for this CD11b Antibody?: The Primärantikörper is referenced in 4 publications and is characterized by a proven, very high reliability. It has currently 7 product images that show its performance in a variety of applications. The product is currently available in 100 μL quantity. CD11b Antibody for the detection of CD11b and derivatives.

What is the function of CD11b?: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Anwendungsinformationen

Applikationshinweise: WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Referenzen für anti-CD11b Antikörper (ABIN741285)

Ju, Xing, Yang, Zheng, Jia, Zhang, Ren: "An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model." in: BMC immunology, Vol. 17, Issue 1, pp. 31, (2016) (PubMed).

Zhang, Wu, Hayashi, Okada, Nakanishi: "Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 8, pp. 3013-22, (2014) (PubMed).

Di Filippo, Rossi, Ferraro, Maisto, De Angelis, Ferraraccio, Rotondo, DAmico: "Involvement of proteasome and macrophages M2 in the protection afforded by telmisartan against the acute myocardial infarction in Zucker diabetic fatty rats with metabolic syndrome." in: Mediators of inflammation, Vol. 2014, pp. 972761, (2014) (PubMed).

Ahn, Ruiz, Barber: "Intrinsic self-DNA triggers inflammatory disease dependent on STING." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 9, pp. 4634-42, (2014) (PubMed).

Details zu CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Andere Bezeichnung: Cd11b/C

Hintergrund:

Synonyms: CD11C, SLEB6, Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p15,95 alpha chain, Leukocyte adhesion receptor p15,95, ITGAX

Background: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Gen-ID: 3687

UniProt: P20702

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation