Rekombinanter Cyclin D3 Antikörper

Produktnummer ABIN7828141

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Cyclin D3 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Cyclin D3 Antikörper (ABIN7828141)

Target: Cyclin D3 (CCND3)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Cyclin D3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A203

Produktdetails anti-Cyclin D3 Antikörper

Verwendungszweck: Recombinant Cyclin D3 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human Cyclin D3 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000,IHC 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu Cyclin D3

Target: Cyclin D3 (CCND3)

Andere Bezeichnung: Cyclin D3

Hintergrund: G1 S specific cyclin D,G1/S specific cyclin D,G1/S-specific cyclin-D,CyclinD,cyclin D,CCND3,cyclin D3,CCND 3,CyclinD3,D3 type cyclin,G1 S specific cyclin D3,G1/S specific cyclin D3,G1/S-specific cyclin-D3,Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 33 kDa

Observed MW: 33 kDa

UniProt: P30281

Pathways: Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process