MYD88 Antikörper (AA 201-296) (Cy3)

Produktnummer ABIN736884

Produktdetails anti-MYD88 Antikörper (Cy3)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Bindungsspezifität: AA 201-296

Reaktivität: Human, Maus, Ratte, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYD88 Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Huhn, Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse MyD88

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Andere Bezeichnung: MyD88 (MYD88 Produkte)

Synonyme: MYD88D antikoerper, XMyD88 antikoerper, myd88d antikoerper, MGC84928 antikoerper, CG2078 antikoerper, DMMYD88 antikoerper, DmMyD88 antikoerper, DmMyd88 antikoerper, Dmel\\CG2078 antikoerper, EP(2)2535 antikoerper, Kra antikoerper, LD20892 antikoerper, MYD88 antikoerper, MyD88 antikoerper, Myd88F antikoerper, dMyD88 antikoerper, dMyd88 antikoerper, kra antikoerper, myd88 antikoerper, zgc:103541 antikoerper, GB12344 antikoerper, NV10640 antikoerper, myd88-a antikoerper, myd88-b antikoerper, myeloid differentiation primary response 88 antikoerper, myeloid differentiation primary response 88 S homeolog antikoerper, myeloid differentiation primary response gene 88 antikoerper, CG2078 gene product from transcript CG2078-RB antikoerper, myeloid differentiation primary response protein MyD88-A antikoerper, myeloid differentiation primary response protein MyD88 antikoerper, myeloid differentiation factor 88 antikoerper, myeloid differentiation primary response 88 L homeolog antikoerper, MYD88 antikoerper, myd88.S antikoerper, Myd88 antikoerper, myd88 antikoerper, LOC413194 antikoerper, LOC100118553 antikoerper, LOC575153 antikoerper, myd88.L antikoerper

Hintergrund:

Synonyms: Myeloid differentiation primary response protein MyD88, Myd88

Background: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Gen-ID: 17874

UniProt: P22366

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades