IL6RA Antikörper (AA 351-460)

Produktnummer ABIN734693

Der Kaninchen Polyklonal Anti-IL6RA-Antikörper wurde für FACS, IF (cc), IF (p), ELISA, IHC (fro) und IHC (p) validiert. Er ist geeignet, IL6RA in Proben von Maus, Human und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für IL6RA Antikörper (AA 351-460) (ABIN734693)

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL6RA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IL6RA Antikörper

Bindungsspezifität: AA 351-460

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse IL-6R alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IL6RA Antikörper (ABIN734693)

Urushima, Fujimoto, Mishima, Ohkawara, Honda, Lee, Kawahata, Serada, Naka: "Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells." in: Arthritis research & therapy, Vol. 19, Issue 1, pp. 137, (2017) (PubMed).

Prystaz, Kaiser, Kovtun, Haffner-Luntzer, Fischer, Rapp, Liedert, Strauss, Waetzig, Rose-John, Ignatius: "Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing." in: The American journal of pathology, Vol. 188, Issue 2, pp. 474-490, (2017) (PubMed).

Details zu IL6RA

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Andere Bezeichnung: IL-6R alpha

Hintergrund:

Synonyms: Il6r, CD126, IL-6R, Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Il6ra

Background: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.

Gen-ID: 16194

UniProt: P22272

Pathways: JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints