ERCC2 Antikörper

Produktnummer ABIN7673032

Dieses Anti-ERCC2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ERCC2 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ERCC2 Antikörper (ABIN7673032)

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-ERCC2 Antikörper

Verwendungszweck: ERCC2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: excision repair cross-complementing rodent repair deficiency, complementation group 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu ERCC2

Target: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Andere Bezeichnung: ERCC2

Hintergrund:

Synonyms: General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD)|Basic transcription factor 2 80 kDa subunit (BTF2 p80)|CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH basal transcription factor complex 80 kDa subunit (TFIIH 80 kDa subunit, TFIIH p80)|Xeroderma pigmentosum group D-complementing protein|ERCC2|XPD|XPDC

Background: ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair(NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase(CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Molekulargewicht: 80 kDa

Gen-ID: 2068

UniProt: P18074

Pathways: DNA Reparatur