IGFBP3 Antikörper

Produktnummer ABIN7670640

Der Maus Monoklonal anti-IGFBP3 Antikörper wird verwendet zum Nachweis von IGFBP3 in Proben von Human. Er wurde validiert für ELISA (Capture).

Kurzübersicht für IGFBP3 Antikörper (ABIN7670640)

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGFBP3 Antikörper ist unkonjugiert

Applikation: ELISA (Capture)

Klon: 13G2

Produktdetails anti-IGFBP3 Antikörper

Verwendungszweck: IGFBP-3 Monoclonal Antibody(Capture)

Aufreinigung: Protein A/G Purification

Immunogen: Recombinant Human IGFBP-3 Protein expressed by Mammalian

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu IGFBP3

Target: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Andere Bezeichnung: IGFBP-3

Hintergrund: InsuLin-Like growth factor-binding protein 3,IBP-3,IGF-binding protein 3,IGFBP-3,IGFBP3,IBP3,The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth,differentiation,and proliferation. IGFBP3 is the most abundant IGF binding protein in human serum and is a growth inhibitory,apoptosis-inducing molecule,capable of acting via IGF-dependent and IGF-independent mechanisms. It appears to function both by cell cycle blockade and the induction of apoptosis. IGFBP3 can be transported to the nucleus by an importin beta mediated mechanism,where it has been shown to interact with the retinoid X receptor alpha and possibly other nuclear elements. IGFBP3 antiproliferative signaling appears to require an active transforming growth factor-beta (TGF-beta) signaling pathway,and IGFBP3 stimulates phosphorylation of the TGF-beta signaling intermediates Smad2 and Smad3. IGFBP3 has IGF-independent roles in inhibiting cell proliferation in cancer cell lines. Nuclear transcription factor,retinoid X receptor (RXR)-alpha,and IGFBP3 functionally interact to reduce prostate tumor growth and prostate-specific antigen in vivo. Several clinical studies have proposed that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers. This includes evidence of a protective effect against breast cancer,prostate cancer,colorectal cancer,and lung cancer. Moreover,IGFBP3 inhibits insulin-stimulated glucose uptake into adipocytes independent of IGF.

UniProt: P17936

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Growth Factor Binding